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Specifically, tobacco-related HNC was enriched within both the diploid and polyploid copy number-high clusters (that is, D1, P1 and P2), while the copy number-silent cluster D2 was mostly constituted by samples from nonsmokers, including cases with unknown risk factors and alcohol drinkers in the absence of tobacco (Supplementary Table 17)

Smoking and secondhand smoke are both dangerous

Research from community reviews on TobaccoReviews indicates that while Virginia is present, the earthy Burley notes are at the forefront, providing a nicotine profile comparable to traditional RYO options