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Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane

Although challenges such as limited bioavailability and safety concerns continue to impede clinical translation, these limitations may be addressed through the optimization of delivery strategies, rigorous pharmacokinetic and toxicological assessments, mechanism-driven in vitro , in vivo , ex vivo studies, and well-designed clinical trials

BCC 1067 enhanced antifungal action of azole drugs through ROS-mediated cell death in yeast

They were briefing-document proposals rather than final determinations at this articles review date