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At the center of these mechanisms are mitochondrial function and the ubiquitous molecule NAD, a metabolite involved in major metabolic pathways (glycolysis and the TCA cycle, among others) and an important cofactor of the pro-reparative sirtuin enzymes

Therefore, the mitochondrial NADH generated by fatty acid beta-oxidation and the cytoplasmic NADPH preserved from inhibition of fatty acid synthesis during fasting may contribute to the reductive redox shift that occurs

Strip the routine back to a gentle cleanser, a barrier-supporting moisturiser, and sunscreen