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Another possible contributor to the observed cigarette smoking-induced epidermal hyperkeratinization is nicotine which has also been shown to increase various differentiation markers including filaggrin, involucrin, TG1 in keratinocytes 19 mediated by the activation of nicotinic acetylcholine receptors abundant in the skin 28

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Differential action of polycyclic aromatic hydrocarbons on endogenous estrogen-responsive genes and on a transfected estrogen-responsive reporter in MCF-7 cells

Bosnia & Herzegovina, where even the cigarette packet (not mine, dad) warnings come in 3 languages - although in this case 2 are identical & 1 is the same with a different alphabet