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The compound's high membrane permeability and metabolic stability make it suitable for both acute and chronic study designs, but researchers should be aware that its effects on NAD+ and methylation metabolism may require time to fully manifest

Liao H, Wang X, Yang C et al (2025) Overexpression of colonic VIP ameliorates cognitive function and barrier system damage caused by sevoflurane anesthesia and surgery in aged rats with fragile brain functions

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