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Jun 1 2019;57(2):133-140

NSAIDs may slightly reduce the inflammatory component of healing, but this is usually not clinically significant

A preference for certain protein nucleophiles has been noted in in chemico assays using skin sensitizers, 14,20,24 but the selectivity of some chemicals for certain nucleophiles is also observed when haptenation is studied in more complex systems in vitro

Temperature extremes (moving from cold air into heated buildings) Hot beverages, spicy foods, and alcohol Stress and intense emotions Exercise and physical exertion These triggers cause temporary redness that typically resolves within 30 minutes to an hour once the stimulus stops