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The mechanism may be related to 5-methyltetrahydrofolate improving the coupling of endothelial nitric oxide synthase 105

For instance, in chimeric human cerebral organoids (chCOs), astrocytes and neurons carrying the APOE4 genotype could jointly promote tau phosphorylation in neurons, closely linked to the role of APOE4 in increasing cholesterol levels and lipid droplet content, suggesting that APOE4 may affect tau phosphorylation in AD by influencing lipid metabolism

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A useful analogy is to imagine the suspension system of a car