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Cerebrolysin has an established safety profile across decades of clinical use, with adverse events occurring in fewer than 5% of patients in Phase IV trials primarily mild injection site reactions, transient dizziness, or headache

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GCLM interacts with GCLC, making the GCL holoenzyme kinetically more efficient in glutathione synthesis since GCLC has a very high Km for l-glutamate compared to when it is complexed with GCLM 32,33