Synthesis of CoQcoumarin conjugates 2-(Hydroxymethyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione 45 (43 mg, 0.20 mmol) and 7-(diethylamino)-2-oxo-2 H -chromene-3-carbonyl chloride 46 (67 mg, 0.24 mmol) were dissolved in CH 2 Cl 2 (2 ml), followed by the addition of Et 3 N (40 l, 0.003 mol) and N , N -dimethylpyridin-4-amine (3 mg, 0.024 mmol)
Clarke GN, Hsieh C, Koh SH, et al
This condition occurs when the arteries in the lungs become narrowed and stiff, forcing the right side of the heart to work harder
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