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Primary Ovarian Insufficiency (POI): Also known as premature ovarian failure or premature menopause, this occurs when the ovaries stop functioning normally before the age of 40, leading to a decline in estrogen production and irregular or absent periods

The study demonstrated that when CXXC5 was knocked out in mice, PGD2 treatment no longer caused hair loss

Tolerability (e.g., gastrointestinal complaints and flushing) of the DMF drug was rated equal or better in most patients, showing that patients can switch form the traditional FAE mixture to the same dose of DMF with similar clinical relief but without any washout period

Free Radic Biol Med 156:107112