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NOX activity and ROS were notably increased in the G6PD-d groups as well

Against this background, our patient had malignancy, prior ICI exposure, severe postoperative pneumonia, and concomitant use of several drugs with potential hepatic and/or cutaneous toxicityconstituting a typical susceptible host plus high-risk drug exposure profile and placing him at dual high risk for both DILI and SJS/TEN

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Indeed, experimental analysis showed that introduction of doxorubicin into physiologically relevant pH media yielded a concentration-dependent oxygen consumption profile, revealing free (non-metal catalysed) auto-oxidation (Fig