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The peripheral inflammatory can be transmitted to the central nervous system by disrupting the BBB, either through humoral or neural pathways such as the vagus nerve

This cytochrome metabolizes some endogenous compounds (e.g., polyunsaturated fatty acids, steroid hormones), small-molecule xenobiotics (e.g., ethanol, carbon tetrachloride), and a relatively small number of drugs for which it is mostly a complementary pathway of metabolism