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DIO1 and DIO convert T4 to active T3 DIO3 converts T4 to inactive reverse-T3 (rT3), and T3 to T2 Because these isozymes or enzymes rely on selenium to function properly, a selenium deficiency can result in thyroid problems and affect iodine excretion

Mol Carcinogenesis (2015) 54:151320

Tryptophan is the precursor (raw material) for serotonin, a neurotransmitter that contributes to feelings of well-being

Experimental studies suggest that DSIP influences the release of stress-related hormones such as adrenocorticotropic hormone and cortisol analogs in animal systems, indicating a role in feedback regulation of neuroendocrine stress pathways [4]