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4- Muscle Regeneration and Anti-Atrophy Protection Preclinical work 6 shows IGF-1 regulates matrix metalloproteinases (MMPs) and cytokines during tissue remodeling, ensuring balanced regeneration and reducing fibrotic scarring.IGF-1 also demonstrates protective effects against muscle atrophy by suppressing ubiquitin-proteasome pathways, helping preserve lean mass even during inactivity

Moreover, NAC exerts anticoagulant and antiplatelet properties, and therefore, its use in patients with bleeding disorders or blood thinners is relatively contraindicated

As such, we hypothesize that the Human-SFB-refML lineage may have become replaced, or outcompeted, by SFB from other lineages in individuals outside of Africa