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As a result, Munch HF, et al

CRP is synthesized in smooth muscle cells of atherosclerotic lesions with active disease, foam cells, macrophages, lymphocytes, monocytes, and endothelial cells within the atherosclerotic plaque (166170)

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Furthermore, existing research has largely focused on transport mechanisms under physiological conditions, while in pathological contextssuch as impaired blood-brain barrier integrity or chronic inflammatory microenvironmentsthese transport patterns may undergo significant reprogramming, with regulatory networks likely far more complex than current models suggest