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In an MCAO/R model using ICR mice, prophylactic administration of PACs via gavage at a minimum dose of 25 mg/kg daily for 7 days enhanced neurological function, reduced infarct volume, and activated the Nrf2/HO-1 signaling pathway

In this sense, adjunctive therapies for specific tumors using these modulators can further improve immunotherapies

Laboratory findings suggest that Epithalon may modulate expression patterns linked to circadian rhythm stability, particularly in aging cellular systems where rhythmic signaling tends to deteriorate

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