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Activity was monitored via quantification of radiolabeled reaction product DNA 5-[methyl- 3 H]-cytosine

Since PRDX2 has been shown to be glutathionylated by GSH at its cysteine residues to protect against its hyperperoxidation 41 , it is possible that elevated GSH levels in T315I-Bcr-Abl cells might prevent PRDX2 monomer formation, therefore abrogating ROS-induced replication stress

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Factors such as temperature, pH and wavelength can impact the stability and efficacy of the combination