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Clinical studies utilizing facial application of 2-3% GHK-Cu serums over 12-week periods have documented measurable improvements across multiple photoaging parameters, including 20-35% reductions in fine line depth, 15-25% improvements in skin elasticity measurements, and 25-40% increases in dermal density as assessed through high-frequency ultrasound imaging

Wilding et al

FOXO4-DRI is studied in the context of cellular senescence, p53 signaling, senolytic research, and biogerontology in preclinical models

If amycretin succeeds, it could make cagrilintide as a standalone product less relevant, though the amylin mechanism it pioneered would live on in the new molecule