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The abnormal expression of GPx2 was detected in different tumors, and GPx2 was up-regulated in colorectal cancer [51, 52] and down-regulated in prostate intraepithelial neoplasia [53], suggesting that GPx2 plays complex roles in tumorigenesis [23]

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(45) combined clinical samples with animal experiments to demonstrate that the expression levels of microRNA-21 (miR-21), phosphorylated Smad2/3 (p-Smad2/3), and T helper 17 (Th17) cell-related cytokines (IL-17A, IL-6) are significantly upregulated in the lung tissue of COPD patients

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