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Dihexa was administered intraperitoneally (i.p.) at 0.5 mg/kg in phosphate buffered saline (PBS) on alternate days, commencing 15 days post-surgery and continuing through day 48, with control animals receiving PBS alone

For example, in the management of chronic infections, AI can detect subtle indicators of disease recurrence before clinical symptoms emerge

N6-methyladenosine (m 6 A) demethylase FTO is significantly upregulated in MPP + -stimulated SK-N-SH cells, which suppresses YTH domain family protein 2 (YTHDF2) expression, promotes m 6 A demethylation of BRCA1-associated protein 1 (BAP1) and enhances BAP1 expression, upregulates p53 expression, and inhibits SLC7A11 transcription, thereby increasing MDA, Fe 2+ , and 4-HNE levels and triggering neuronal ferroptosis

Dooling SW, Sgritta M, Wang I-C, Duque ALRF, Costa-Mattioli M