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[8] Compared with saline, delayed T4 did not shrink the lesion volume a telling detail, because it means the benefit was not simply less initial damage yet it significantly reduced hippocampal cell loss, enhanced angiogenesis and neurogenesis in the injured cortex and hippocampus, increased oligodendrogenesis, and improved sensorimotor recovery and spatial learning

These behavioral benefits are underpinned by its marked ability to induce spinogenesis and promote functional synaptogenesis in hippocampal neurons, highlighting its potential as a robust procognitive and antidementia agent [2]

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