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Encouragingly, experiments show that antioxidant interventions in aged animals (including administering melatonin or vitamin E) can restore some amplitude to circadian rhythms and improve activity/rest pattern stability ( Melatonin is unique among endogenous antioxidants because of its efficiency and ubiquity: it can donate electrons to neutralize radicals, and its metabolites (like AFMK) are also free radical scavengers, yielding a cascade of antioxidant actions

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