Microbial/infection Many specialists have considered IC/PBS to possibly have an infectious origin (bacterial, viral, or fungal) because microorganisms like Helicobacter pylori have been found in association with the condition, which draws parallels to chronic gastritis (Atu et al., 2004
A deficiency can also cause a condition called megaloblastic anemia which creates larger, immature, and abnormal red blood cells and leads to impaired DNA synthesis
Reducing excess pressure on the feet helps long-term healing
CD36, a fatty acid transporter, increases the uptake of fatty acids by CD8+ T cells in the TME, leading to the inhibition of their effector function, reduced production of cytotoxic factors, such as perforin and granzymes, and weakened anti-tumor capacity