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Neuropsychiatric disease and treatment 4(1):6979 Mignot E et al (2022) Safety and efficacy of daridorexant in patients with insomnia disorder: results from two multicentre, randomised, double-blind, placebo-controlled, phase 3 trials

This is a structural pharmacology difference, not a dose difference at equivalent GH-stimulating doses, it produces minimal cortisol and prolactin elevation, while GHRP-6 produces significant elevations of both

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