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For example, studies have demonstrated that melatonin supplementation during in vitro maturation (IVM) can upregulate the expression of genes related to oocyte maturation, such as GDF9, BMP15, and PTX3 (77)

It is also synthesized in the placenta in pregnant women and can be found in high concentrations in breast milk.567 One of the major roles of inositol in the body is the production of inositol triphosphate, which is an essential second messenger for hormones such as insulin and follicle stimulating hormone.6 Choline Choline is an essential nutrient that plays a key role in a number of metabolic pathways in the human body

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doi: 10.1371/journal.pone.0031131 206 SofiaMACiorbaMAMeckelKLimCKGuilleminGJWeberCRet al