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Mice were first pretreated with distilled water or antibiotic mixture for 2 weeks, then pretreated with distilled water or 100 l WECSL (1.0 g/ml, gavage) for 2 weeks, followed by loperamide injection (10.0 mg/kg, twice daily) for 2 weeks to induce constipation

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For example, rat TDSCs treated with IGF-1 (1, 10, and 100 ng/mL) for 28 days exhibited the increased expression of tendon-specific marker (SCX) and significantly decreased expression of chondrogenic and osteogenic marker (collagen type II) ( in vitro culture with significant upregulation of tenocytic markers (SCX, collagen type III, and decorin) ( in vivo data are available regarding the efficacy of exogenously delivery of IGF-1 in combination with stem cells to treat tendon injury