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The process is dynamic, and involves also the thiolate groups of proteins such as serum albumin and haemoglobin and appears as the main mechanism for the distribution of thiol-binding metals from the absorption site throughout the body and towards the active sites where the toxic action is developed at the molecular level

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Beyond its previously reported modulation of autophagy via the Phosphatidylinositol 3-Kinase (PI3K)/AKT Serine/Threonine Kinase (AKT)/Mechanistic Target of Rapamycin (mTOR) pathway and NF-B inhibition 61,62 , our findings revealed that palmatine s mechanism involves a novel target network