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It is this dynamic that has made measurement of serum ceruloplasmin the primary screening test for Wilsons.16 Ultimately, the excess retained copper in the hepatocytes of Wilsons patients leads to toxic injury to the cell and eventually spillage of copper into the circulation, where it may be deposited in other organs such as the brain, cornea, and kidneys

doi: 10.1016/j.cub.2023.02.060 80 ForetMKLincolnRDo CarmoSCuelloACCosaG

Functional assessments Range of motion: Goniometer measurements or functional testing (how far can joint move)

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