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A lot of evidence has shown that excessive activation of NMDARs in AD is related to changes in the expression of calpain, Ca 2+ /CaMKII, GSK-3, and other proteins, which play crucial roles in excitotoxicity and neurodegeneration [151]

Gonadotropin releasing hormone agonists, such as goserelin, are employed to induce a hypoestrogenic state by initially stimulating and then downregulating pituitary hormone secretion, whereas gonadotropin releasing hormone antagonists, directly block receptor binding for a more rapid onset of action (5)

10.1111/nyas.13930 136 SkoutaR.DixonS

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