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In mouse models of cerebral or renal artery occlusion, pretreatment with UroA appeared to mitigate the effects of ischaemia, reducing the extent of tissue damage and restoring impaired autophagy (Reference Wang, Huang and Jin62, Reference Ahsan, Zheng and Wu63)

Arginine synthesis is impaired when small intestine and kidney function is impaired, thus creating a dietary requirement for arginine

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