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A 2025 pilot human IV study at 1020mg reported a favorable safety profile with no serious adverse events

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This links ubiquitination and neddylation, indicating that neddylation affects the ubiquitination levels of target proteins affiliated with ubiquitin E3 ligases

Its importance in the body cant be over-estimated - low levels have been associated with several different illnesses and conditions, such as cardiovascular disease (where the health of blood vessels is crucial and glutathione may help protect them), cancer, arthritis, and more