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however, TRPM8 inhibition restored activity to control levels in methylglyoxal-treated cells, suggesting a specific interaction between methylglyoxal and TRPM8, as previously reported ( Airliquid interface (ALI) exposures to acetaldehyde or methylglyoxal also disrupted cytoskeletal organization in EpiAirway tissues, as indicated by Gene Ontology (GO) terms related to cadherin binding, focal adhesion, and cellsubstrate junctions, and by predictions from Ingenuity Pathway Analysis (IPA)

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"Things like this are a good warning sign," he says

Its highly addictive, with roughly 15 million Americans meeting criteria for alcohol use disorder